Chronic granulomatous disease (CGD)

Chronic granulomatous disease (CGD) is a hereditary disease  presenting primarily in childhood characterized by a defect in the   NADPH ( nicotinamide adenine dinucleotide phosphate - reduced form)  oxidase enzyme of phagocytes, impairing their ability to produce bactericidal superoxide anions.  Affected individuals present with recurrent bacterial and fungal infections which may be life-threatening.  The organs most commonly involved are the skin, lungs, GI tract, lymph nodes, liver, and spleen.

The microscopic features are non-specific consisting of active chronic inflammation, with or without abscess or granuloma formation. Pigmented macrophages are sometimes numerous. 

Photomicrographs of Chronic Granulomatous Disease (CGD)

Lung, microabscess with surrounding mononuclear (granulomatous) cellular infiltrate

Lung, non-necrotizing granuloma with surrounding non-specific chronic inflammation