Extrapulmonary Sarcoidosis
Sites other than the lungs
Microscopic appearances
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Heart- Granulomatous (giant cell) myocarditis , medium magnification (courtesy of Akio Hasegawa, M.D.-with permission)
Heart- Granulomatous (giant cell) myocarditis , high magnification (courtesy of Akio Hasegawa, M.D-with permission)
Liver - Granulomas and fibrosis involving portal triad.
Bone marrow
Female breast
Skeletal muscle
Although sarcoidosis is limited to the lungs and adjacent lymph nodes in most patients, the granulomas may involve any part of the body or organ system and produce clinical manifestations referable to involvement of those extrapulmonary sites. The microscopic appearances of some examples of extrapulmonary involvement are shown below.
Liver - Parenchymal granuloma
Brain, cerebellum, granulomatous angiitis
Brain, granulomatous angiitis
Peritoneum, granulomatous angiitis
Urinary bladder
Mediastinal lymph node
Mediastinal lymph node