Extrapulmonary Sarcoidosis

Sites other than the lungs

Microscopic appearances

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Heart- Granulomatous (giant cell) myocarditis , medium magnification (courtesy of Akio Hasegawa, M.D.-with permission)

Heart- Granulomatous (giant cell) myocarditis , high magnification (courtesy of Akio Hasegawa, M.D-with permission)

Liver - Granulomas and fibrosis involving portal triad.

Bone marrow

Female breast

Skeletal muscle

Although sarcoidosis is limited to the lungs and adjacent lymph nodes in most patients, the granulomas may involve any part of the body or organ system and produce clinical manifestations referable to involvement of those extrapulmonary sites. The microscopic appearances of some examples of extrapulmonary involvement are shown below.

Liver - Parenchymal granuloma

Brain, cerebellum, granulomatous angiitis

Brain, granulomatous angiitis

Peritoneum, granulomatous angiitis

Urinary bladder

Mediastinal lymph node

Mediastinal lymph node

Skin

Skin