Palisading Granulomas

Palisading granulomas are a subtype of necrotizing granuloma in which the mononuclear phagocytes at the periphery have  elongated or spindle-shaped nuclei that are palisaded and arranged roughly parallel to each other and roughly perpendicular to the edge of the  central necrotic zone.

The most common are rheumatoid nodules and post-surgical necrobiotic granulomas occurring in the prostate, urinary bladder, and other sites. They have also been reported in Churg-Strauss disease, foreign body granulomatous reactions, cutaneous T-cell lymphoma, Wegener’s granulomatosis, and a in a variety of infections (non-tuberculous mycobacteriosis, cat scratch disease, phaeohyphomycosis, sporotrichosis, cryptococcosis, coccidioidomycosis, syphilis)

Fibrin ring granuloma. Q fever. Liver

Click on the following links to view microscopic images

Rheumatoid nodule, subcutaneous, low magnification

Rheumatoid nodule, early lesion, subcutaneous

Rheumatoid nodule, palisading histiocytes,, subcutaneous

Rheumatoid nodule, pleura

Necrobiotic post-TUR granulomas, prostate, low magnification

Necrobiotic post-TUR granuloma, prostate

Necrobiotic post-TUR granuloma, palisading histiocytes, prostate