Chronic granulomatous disease (CGD)
Chronic granulomatous disease (CGD) is a hereditary disease  presenting primarily in childhood characterized by a defect in the   NADPH ( nicotinamide adenine dinucleotide phosphate - reduced form)  oxidase enzyme of phagocytes, impairing their ability to produce bactericidal superoxide anions.  Affected individuals present with recurrent bacterial and fungal infections which may be life-threatening.  The organs most commonly involved are the skin, lungs, GI tract, lymph nodes, liver, and spleen.

The microscopic features are non-specific consisting of active chronic inflammation, with or without abscess or granuloma formation. Pigmented macrophages are sometimes numerous. 
Photomicrographs of Chronic Granulomatous Disease (CGD)