Chronic granulomatous disease (CGD)
Chronic granulomatous disease (CGD) is a hereditary disease presenting primarily in childhood characterized by a defect in the NADPH ( nicotinamide adenine dinucleotide phosphate - reduced form) oxidase enzyme of phagocytes, impairing their ability to produce bactericidal superoxide anions. Affected individuals present with recurrent bacterial and fungal infections which may be life-threatening. The organs most commonly involved are the skin, lungs, GI tract, lymph nodes, liver, and spleen.
The microscopic features are non-specific consisting of active chronic inflammation, with or without abscess or granuloma formation. Pigmented macrophages are sometimes numerous.
Photomicrographs of Chronic Granulomatous Disease (CGD)